Synthesis, characterization and fungicidal activity of novel 2-aminopyrimidine Schiff bases

Abstract

2-Aminopyrimidines represents vital class of bioactive molecules where its structural changes would lead to its peculiar properties. N-heterocyclic compound i.e. 2-aminopyrimidine had wide range of applications in pharmacological, material chemistry and agriculture as antifungal, antimicrobial and antibacterial agents. 2-Aminopyrimidine and its derivatives are good candidates for antimicrobial, antifungal and anticorrosion activity. In the present study, a series of substituted N-benzylidine-2-aminopyrimidine compounds have been synthesized by condensation reaction of 2-aminopyrimidine with substituted benzaldehydes (o-chloro, m-hydroxybenzaldehyde, p-hydroxybenzaldehyde, 2,5-dimethoxybenzaldehyde, p-dimethylaminobenzaldehye, syringaldehyde, o-phthaldehyde, isovanillin benzaldehyde, veratraldehyde and thiophene-2-carboxyaldehyde) using glacial acetic acid or NaOH (40%). The synthesised Schiff bases have been characterized using UV, IR, ¹H NMR and ¹³C spectral studies. 2-Aminopyrimidine Schiff bases (1-10) have been examined for fungitoxicity on the growth of Fusarium verticillioides, Rhizoctonia solani and Macrophomina phaseolina using poisoned food technique.