Silica sulfuric acid catalyzed green synthesis of 1,2- dihydro-1-aryl naphtho[1,2-e][1,3]-oxazin-3-one and 1,2- dihydro-1-methyl naphtho[1,2-e][1,3]-oxazin-3-one as potent antibacterial agents

Abstract

A simple, efficient and green method for the preparation of naphthooxazinones employing easily available reagents
2-naphthol, aldehydes, urea and silica sulphuric acid (SSA) as catalyst is reported. The microwave assisted multi component reaction (MCR) procedure provides multiple advantages inclusive of short reaction times, high yields, easy work-up, catalyst recovery and reusability which proves to be environmentally benign. Studies on the antibacterial properties of the synthesized heterocyclic compounds have been done through in vitro methods against gram-positive and gram-negative bacteria.