Anti-Oxidant potential of Herbal formulation (Sahaj Vati) Modulating Leptin, Insulin activity

Abstract

Obesity increased at alarming rate considered as serious health risks and World Health Organization wish to halt rise of obesity. Therefore, search for treatment, dietary interventions is necessary to attenuate and/or prevent the obesity. Sahaj Vati was prepared by Shilajeet, Curcuma longa, Plumbago zeylanica, Commiphora mukul and might be reduces obesity. Twenty four albino rats were randomized into four equal groups were selected as control, positive control, as standard (orlistate) and Sahaj Vati treated group, respectively. Monosodium glutamate (MSG) was administered at dose of 10 mg/kg body weight for 10 days and Sahaj Vati & orlistate was administered orally at dose of 200 and 10 mg/kg body weight respectively for four week. After four week, body weight of animals, serum leptin, insulin, total oxidant, total antioxidant and oxidative stress index were estimated. It was observed that body weight was significantly increased by MSG whereas body weight, was significantly decreased by orlistat and Sahaj Vati. Sahaj Vati significantly increased insulin concentration, total anti-oxidant status and decreased total oxidant status & oxidative stress and significantly decreased leptin concentration.  Thus, Sahaj Vati decreases body weight by modulating leptin & insulin concentration as well as total oxidant status, total anti-oxidant status & oxidative stress.