Theoretical and experimental studies of novel histidine derived Schiff base metal complexes, active towards biomedical and MCF 7 cell lines

Abstract

Novel tri-dentate ligand-metal complexes [Mn(II), Co(II), Cu(II), Ni(II) and Zn(II) (1-5)] have been synthesized using L-histidine amino acid derived Schiff base ligand and characterized using analytical and spectral methods like UV-visible, FT-IR and ESI-MS techniques. The antioxidant studies of the Schiff base ligand and 1-5 complexes reveal that complexes exhibit significant free radical scavenging activity against the free radical DPPH. In vitro cytotoxic activity of the 1-5 complexes evaluated against the breast cancer cell lines (MCF-7), reveal that complex 3 exhibits higher cytotoxicity than any other synthesized metal complexes. The docking studies have been carried out using BSA protein and DNA biomolecules with synthesized metal complexes. Antimicrobial studies has demonstrated that Cu(II) complexes possess higher activity against both Gram positive and Gram negative bacteria as well as Fungi.